01 /What it is
Spadin is a 17 amino acid peptide derived from the propeptide of sortilin. It is the parent sequence from which PE-22-28 was derived.
02 /How it works
In research models, Spadin is studied as a selective blocker of the TREK-1 potassium channel, with downstream effects investigated in synaptic plasticity and serotonergic signaling.
03 /What researchers explore it for
Researchers have explored Spadin in synaptic plasticity research, in TREK-1 channel research, and in mood model research.
04 /Safety and interactions
Pairing with other nootropic peptides is commonly studied together. Spadin is for laboratory research use only and is not for human consumption. Not medical advice. Not intended to diagnose, treat, cure, or prevent any disease.
05 /Research notes
Peptide family: sortilin propeptide derivatives. PE-22-28 is the truncated active fragment. Commonly researched alongside Semax.