01 /What it is
PE-22-28 is a seven amino acid peptide derived from a sequence within spadin, itself a fragment of the sortilin propeptide. It is studied for activity at the TREK-1 channel.
02 /How it works
In research models, PE-22-28 is studied in pathways related to TREK-1 potassium channel modulation and downstream effects on synaptic plasticity and serotonergic signaling.
03 /What researchers explore it for
Researchers have explored PE-22-28 in synaptic plasticity research, in mood model research, and in TREK-1 channel research.
04 /Safety and interactions
Pairing with other nootropic peptides is commonly studied together. PE-22-28 is for laboratory research use only and is not for human consumption. Not medical advice. Not intended to diagnose, treat, cure, or prevent any disease.
05 /Research notes
Peptide family: spadin fragments. Frequently compared with P21 in synaptic plasticity research. Commonly researched alongside Semax.