01 /What it is
Histatin 5 is a 24 amino acid histidine rich peptide produced by the parotid and submandibular salivary glands. It is part of the histatin family that researchers identify as one of the most studied oral cavity antimicrobial peptides, with notable activity against the yeast Candida albicans in research models.
02 /How it works
In research models, Histatin 5 enters Candida albicans cells through the Dur3 and Dur31 polyamine transporters and accumulates in the mitochondria, where it disrupts the electron transport chain and triggers reactive oxygen species production that researchers measure as the antifungal readout.
03 /What researchers explore it for
Researchers have explored Histatin 5 in antifungal research, in oral cavity immune research, and in mitochondrial targeted antimicrobial research.
04 /Safety and interactions
Histatin 5 is for laboratory research use only and is not for human consumption. Not medical advice. Not intended to diagnose, treat, cure, or prevent any disease.
05 /Research notes
Peptide family: histatin family antimicrobial peptides. Frequently compared with Lactoferrin in oral cavity defense research and with LL-37 in broader antimicrobial research. The Apothify library lists Histatin 5 for encyclopedia coverage only.
Related peptides
Lactoferrin · LL-37 · Magainin II
