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Growth hormone research.

Peptides explored in growth hormone axis research, including GHRH analogs, ghrelin receptor agonists, and IGF-1 family compounds. Browse the full Apothify research library.

About this research area

The growth hormone axis is the most studied signaling chain in peptide research.

The growth hormone axis is one of the most studied signaling chains in modern peptide research. Apothify groups three peptide families under this category. GHRH analogs (Sermorelin, CJC-1295, Tesamorelin) copy the body's own growth hormone releasing hormone signal. Ghrelin receptor agonists (Ipamorelin, GHRP-2, GHRP-6, Hexarelin) act on a separate receptor in the same pathway. Downstream growth factor analogs (IGF-1 LR3, MGF) let researchers study what happens after the signal has fired.

Growth hormone is released in pulses, not as a steady flow. Researchers measure how a given peptide changes the timing, amplitude, and selectivity of those pulses. A GHRH analog paired with a ghrelin receptor agonist produces a larger and more natural pulse in laboratory models than either compound alone. That pairing is the most compared two compound combination in the published literature.

Across this category, three properties get compared most often: selectivity, half life, and pulse pattern. The Compare tool lines up two compounds on those properties side by side. Every entry follows the same five section format so two entries can be reviewed point by point.

CJC-1295 (no DAC)
No. 01 · growth hormone
CJC-1295 (no DAC)

A GHRH analog commonly investigated in growth hormone axis research without the DAC modification.

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Ipamorelin
No. 02 · growth hormone
Ipamorelin

A selective ghrelin receptor agonist commonly paired with GHRH analogs in growth hormone research.

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GHRP-2
No. 03 · growth hormone
GHRP-2

A growth hormone releasing peptide commonly paired with GHRH analogs in growth hormone research.

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GHRP-6
No. 04 · growth hormone
GHRP-6

A ghrelin receptor agonist commonly studied in growth hormone and appetite related research models.

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Hexarelin
No. 05 · growth hormone
Hexarelin

A potent ghrelin receptor agonist explored in growth hormone axis and cardiac research.

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IGF-1 LR3
No. 06 · growth hormone
IGF-1 LR3

A long acting analog of IGF-1 commonly investigated in growth factor and cell biology research.

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CJC-1295 with DAC
No. 07 · growth hormone
CJC-1295 with DAC

A long acting GHRH analog studied in growth hormone axis research with the drug affinity complex modification.

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Sermorelin
No. 08 · growth hormone
Sermorelin

A GHRH analog commonly investigated in growth hormone axis research.

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Tesamorelin
No. 09 · growth hormone
Tesamorelin

A stabilized GHRH analog researched in lipid and growth hormone axis models.

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Modified GRF 1-29
No. 10 · growth hormone
Modified GRF 1-29

A GHRH analog widely sold under multiple names; refer to CJC-1295 (no DAC) for the same molecule.

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MGF
No. 11 · growth hormone
MGF

A splice variant of the IGF-1 gene investigated in muscle and tissue research models.

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GHRP-1
No. 12 · growth hormone
GHRP-1

An early growth hormone releasing peptide studied in pulsatile growth hormone axis research.

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Alexamorelin
No. 13 · growth hormone
Alexamorelin

A hexapeptide growth hormone secretagogue studied in growth hormone axis research.

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Pralmorelin
No. 14 · growth hormone
Pralmorelin

The international name for GHRP-2, a growth hormone releasing peptide.

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MK-677 (Ibutamoren)
No. 15 · growth hormone
MK-677 (Ibutamoren)

An orally active growth hormone secretagogue studied at the ghrelin receptor. Non peptide research compound.

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Tabimorelin
No. 16 · growth hormone
Tabimorelin

A long acting peptidomimetic growth hormone secretagogue investigated in older GHS research.

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Anamorelin
No. 17 · growth hormone
Anamorelin

An orally available ghrelin receptor agonist investigated in clinical and preclinical research.

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Macimorelin
No. 18 · growth hormone
Macimorelin

An oral ghrelin receptor agonist used as a research tool for growth hormone stimulation.

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